Kathy Keqin Li

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PI (Principle Investigator) 
Shanghai Hematology Institute, Shanghai Jiaotong University.

US-SINO Epigenetic Association (http://www.epigenetic.us).

 
Professional Headshot of Kathy Keqin Li

Mailing Address

Science and Education Plaza,197 Ruijin II road,Shanghai 20025,China.   &
P.O.Box 931703, Norcross, Georgia 30003,
United States

Contact Information

Phone: +86-13661798249     +1-6786137777
kli@epigenetic.us
http://epigenetic.us/kli.htm

Qualifications

Ph.D., Beijing Basic Medicine Institute, Medicine, 2001.

Postdoctor, The Wistar Institute, University of Pennsylvania, 2002-2006.

Senior Scientist, Medical School, Emory University, 2006-2009.

Publications

           
    • Yan X, Xu J, Gu Z, Pan C, Shi J, Shen Y, Song H, Li KK, Chen S, Chen Z. "Exome Sequencing Reveals Frequent Mutations of DNA Methyltransferase Gene DNMT3A with Significant Clinical Relevance in Acute Monocytic Leukemia". Nature Genetics. 2011 . Accepted. 
    • Mao JH, Sun XY, Liu JX, Zhang QY, Liu P, Huang QH, Li KK, Chen Q, Chen Z, Chen SJ. (Nov. 2010). As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia. Proc Natl Acad Sci U S A. 2010 Abstract
    • Li KK, Luo C, Wang D, Jiang H, Zheng YG.,  (Nov. 2010) Chemical and biochemical approaches in the study of histone methylation and demethylation, Medicinal Research Review, 2010.  Abstract
    • Li K, Ossareh-Nazari B, Liu X, Dargemont C, Marmorstein R (Sept. 2007) Molecular basis for bre5 cofactor recognition by the ubp3 deubiquitylating enzyme., Journal of molecular biology, 372 (1), 194-204 Abstract
    • Li K., Ooi SK., Qiu C., E. Bernstein, J. Da, Z. Yang, E. H, Lin SP, Allis CD, Cheng X, Bestor TH (Aug. 2007) DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA., Nature, 448 (7154), 714-7 Abstract
    • Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB (Dec. 2006) Acetylation of the p53 DNA-binding domain regulates apoptosis induction., Molecular cell, 24 (6), 841-51 Abstract
    • Li K, Zhao K, Ossareh-Nazari B, Da G, Dargemont C, Marmorstein R (Aug. 2005) Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor., The Journal of biological chemistry, 280 (32), 29176-85 Abstract
    • Emre NC, Ingvarsdottir K, Wyce A, Wood A, Krogan NJ, Henry KW, Li K, Marmorstein R, Greenblatt JF, Shilatifard A, Berger SL (Feb. 2005) Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing., Molecular cell, 17 (4), 585-94 Abstract
    • Yan C, Tian F, Xiao F, Li K, Li C (Jan. 2002) [Adhesion induces matrix metalloproteinase-9 gene expression in ovarian cancer cells], Zhonghua zhong liu za zhi [Chinese journal of oncology], 24 (1), 17-9 Abstract

    Expertise and Research Interests (download my research work)

    PhD in medicine, several years academic experience in University of Pennsylvania and Emory University, with emphasis in protein biochemistry and epigenetics. One of my paper was published in prestigious peer-reviewed journal of "Nature".

    Honors and Awards

    2002, Excellent Doctoral Graduates, Beijing Basic Medicine Institute
    2001, Excellent Young Investigator of Cancer Research, China Anti-tumor Association
    2008, TCP ("Transforming Community Project") mini-grant, Emory TCP office

    Other Expertise

    Had been the chair of International Committee of Postdoctor Office in Emory University.

    Future Research

    Epigenetic Marker of Cancer Cell, Tumor immunology, Oncology, Structural Based Drug Design.

    Memberships

    American Association for the Advancement of Science
    American Crystallographic Association

    Keywords

    Drug Screening, Biochemistry, Cancer Biology, DNA Repair, Drug Design, Genetic Diseases, Genetic Markers, Mental Retardation, Structural Biology.

    Epigenetics, Histone Code, Peptide Synthesis, Protein Purification, X-ray Crystallagraphy.

    Profile Details

    Last Updated: 10/1/2010