PI (Principle Investigator)
Shanghai Hematology Institute, Shanghai Jiaotong University.
US-SINO Epigenetic Association (http://www.epigenetic.us).
Ph.D., Beijing Basic Medicine Institute, Medicine, 2001.
Postdoctor, The Wistar Institute, University of Pennsylvania, 2002-2006.
Senior Scientist, Medical School, Emory University, 2006-2009.
- Yan X, Xu J, Gu Z, Pan C, Shi J, Shen Y, Song H, Li KK, Chen S, Chen Z. "Exome Sequencing Reveals Frequent Mutations of DNA Methyltransferase
Gene DNMT3A with Significant Clinical Relevance in Acute Monocytic
Leukemia". Nature Genetics. 2011 . Accepted.
- Mao JH, Sun XY, Liu JX, Zhang QY, Liu P, Huang QH, Li KK, Chen Q, Chen Z, Chen SJ. (Nov. 2010). As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia. Proc Natl Acad Sci U S A. 2010
- Li KK, Luo C, Wang D, Jiang H, Zheng YG., (Nov. 2010) Chemical and biochemical approaches in the study of histone methylation and demethylation, Medicinal Research Review, 2010.
K, Ossareh-Nazari B, Liu X, Dargemont C, Marmorstein R (Sept. 2007)
Molecular basis for bre5 cofactor recognition by the ubp3
deubiquitylating enzyme., Journal of molecular biology, 372 (1), 194-204
- Li K., Ooi SK., Qiu C., E. Bernstein, J. Da, Z. Yang, E. H, Lin SP, Allis
CD, Cheng X, Bestor TH (Aug. 2007) DNMT3L connects unmethylated lysine 4
of histone H3 to de novo methylation of DNA., Nature, 448 (7154), 714-7
SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB
(Dec. 2006) Acetylation of the p53 DNA-binding domain regulates
apoptosis induction., Molecular cell, 24 (6), 841-51
K, Zhao K, Ossareh-Nazari B, Da G, Dargemont C, Marmorstein R (Aug.
2005) Structural basis for interaction between the Ubp3
deubiquitinating enzyme and its Bre5 cofactor., The Journal of biological chemistry, 280 (32), 29176-85
NC, Ingvarsdottir K, Wyce A, Wood A, Krogan NJ, Henry KW, Li K,
Marmorstein R, Greenblatt JF, Shilatifard A, Berger SL (Feb. 2005)
Maintenance of low histone ubiquitylation by Ubp10 correlates with
telomere-proximal Sir2 association and gene silencing., Molecular cell, 17 (4), 585-94
C, Tian F, Xiao F, Li K, Li C (Jan. 2002) [Adhesion induces matrix
metalloproteinase-9 gene expression in ovarian cancer cells], Zhonghua zhong liu za zhi [Chinese journal of oncology], 24 (1), 17-9
PhD in medicine, several years academic experience in University of
Pennsylvania and Emory University, with emphasis in protein
biochemistry and epigenetics. One of my paper was published in
prestigious peer-reviewed journal of "Nature".
Honors and Awards
2002, Excellent Doctoral Graduates,
Beijing Basic Medicine Institute
2001, Excellent Young Investigator of Cancer Research,
China Anti-tumor Association
TCP ("Transforming Community Project") mini-grant,
Emory TCP office
Had been the chair of International Committee of Postdoctor Office in Emory University.
Epigenetic Marker of Cancer Cell, Tumor immunology, Oncology, Structural Based Drug Design.
American Association for the Advancement of Science
American Crystallographic Association
Drug Screening, Biochemistry, Cancer Biology, DNA Repair, Drug
Design, Genetic Diseases, Genetic Markers, Mental Retardation,
Epigenetics, Histone Code, Peptide Synthesis, Protein Purification, X-ray Crystallagraphy.
Individual Expertise profile of Kathy Keqin Li, Copyright Kathy Keqin Li.